BALB/c Mice Resist Infection with Bartonella bacilliformis
Author Information
Author(s): Infante Beronica, Villar Sandra, Palma Sandra, Merello Jenny, Valencia Roberto, Torres Luis, Cok Jamie, Ventosilla Palmira, Manguiña Ciro, Guerra Humberto, Henriquez Cesar
Primary Institution: Instituto de Medicina Tropical Alexander von Humboldt – Universidad Peruana Cayetano Heredia, Lima, Perú
Hypothesis
Can BALB/c mice be experimentally infected with Bartonella bacilliformis?
Conclusion
BALB/c mice did not show any signs of infection or organ lesions after being inoculated with Bartonella bacilliformis.
Supporting Evidence
- No cultivable organisms were found in the spleen, liver, or lymph nodes of the inoculated mice.
- Mice showed no lesions in any organs after inoculation.
- One mouse had liver abscesses, but it was also observed in a control mouse.
Takeaway
The study found that BALB/c mice didn't get sick or show any damage after being given a bacteria that usually causes disease in humans.
Methodology
BALB/c mice were inoculated with different doses of live B. bacilliformis via various routes and monitored for signs of infection.
Limitations
The study did not successfully isolate the bacteria from the mice, indicating potential limitations in the model used.
Participant Demographics
BALB/c mice, 10-12 weeks old.
Digital Object Identifier (DOI)
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