Stool Microbiota Signatures in Newborns at Risk of Atopy
Author Information
Author(s): Yap Gaik Chin, Chee Kok Keong, Hong Pei-Ying, Lay Christophe, Satria Cahya D, Sumadiono, Soenarto Yati, Haksari Ekawaty L, Aw Marion, Shek Lynette Pei-Chi, Chua Kaw Yan, Zhao Yudong, Leow Doreen, Lee Bee Wah
Primary Institution: National University of Singapore
Hypothesis
Demographic and lifestyle factors influence the composition of fecal microbiota in newborns.
Conclusion
Differences in stool microbiota signatures were observed in relation to various demographic factors.
Supporting Evidence
- Vaginal delivery was more common in Singapore compared to Indonesia.
- Breastfeeding practices differed significantly between the two cohorts.
- Mode of delivery had the largest effect on stool microbiota signatures.
Takeaway
The way babies are born and fed can change the types of bacteria in their poop, which might affect their health later on.
Methodology
The study used molecular techniques like T-RFLP and FISH-FC to analyze stool samples from infants at four time points.
Potential Biases
Potential biases may arise from differences in socioeconomic status and cultural practices between the two cohorts.
Limitations
The study may not account for all confounding factors affecting microbiota composition.
Participant Demographics
Participants included 42 infants from Singapore and 32 from Indonesia, with varying modes of delivery and feeding practices.
Statistical Information
Confidence Interval
95% CI: 5.063-10.453
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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