Genetic Factors in Obsessive-Compulsive Disorder
Author Information
Author(s): Tibrewal Prashant, Kiran Kumar H.B., Shubha G.N., Subhashree D., Purushottam Meera, Thennarasu K., Reddy Y.C.J, Jain Sanjeev
Primary Institution: National Institute of Mental Health & Neurosciences, Bangalore, India
Hypothesis
Is there an association between serotonin transporter gene polymorphisms and obsessive-compulsive disorder (OCD) in a south Indian population?
Conclusion
The study found no significant association between serotonin transporter gene polymorphisms and OCD in the population studied.
Supporting Evidence
- Genetic variation in the SLC6A4 gene regulatory region may not significantly affect OCD.
- Severity of OCD showed a modest association with the dominant model of the 5-HTTLPR genotype.
- The study included only adults with OCD without co-morbid tic disorder to reduce heterogeneity.
Takeaway
The researchers wanted to see if certain genes were linked to OCD, but they didn't find a strong connection in the people they studied.
Methodology
93 OCD patients and 92 healthy controls were genotyped for serotonin transporter polymorphisms and compared using chi-square tests and linear regression.
Potential Biases
The study may be biased due to the higher proportion of male subjects in the sample.
Limitations
The small sample size may limit the statistical power of the findings.
Participant Demographics
Participants were adults of south Indian origin, with 62 males in both cases and controls.
Statistical Information
P-Value
0.036
Statistical Significance
p=0.036
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