Effects of ATP and Adenosine on Intestinal Permeability Changes
Author Information
Author(s): Bours Martijn JL, Bos Hilde J, Meddings Jon B, Brummer Robert-Jan M, van den Brandt Piet A, Dagnelie Pieter C
Primary Institution: Maastricht University
Hypothesis
Does oral administration of ATP and adenosine in enteric-coated capsules affect indomethacin-induced permeability changes in the human small intestine?
Conclusion
ATP and adenosine administered via enteric-coated capsules had no effect on indomethacin-induced small intestinal permeability changes in healthy human volunteers.
Supporting Evidence
- Median urinary lactulose/rhamnose excretion ratio in the control condition was 0.032.
- Indomethacin plus placebo significantly increased the lactulose/rhamnose ratio to 0.039.
- Neither ATP nor adenosine affected the indomethacin-induced increase in permeability.
Takeaway
This study tested if a supplement could help protect the gut from damage caused by a common painkiller, but it didn't work as hoped.
Methodology
Healthy volunteers ingested indomethacin and either ATP or adenosine in capsules, and their intestinal permeability was measured using a sugar absorption test.
Limitations
The study did not confirm the previously observed benefits of ATP due to potential differences in the site of action.
Participant Demographics
33 healthy volunteers (7 males, 26 females; mean age 22 years)
Statistical Information
P-Value
p<0.01
Confidence Interval
0.022–0.044
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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