Hormones and Diabetes Risk in African Women
Author Information
Author(s): Goedecke Julia H., Kufe Clement Nyuyki, Masemola Maphoko, Lichaba Mamosilo, Seipone Ikanyeng D., Mendham Amy E, Gibson Hylton, Hawley James, Selva David M., Magodoro Itai, Kengne Andre Pascal, Chikowore Tinashe, Crowther Nigel J., Norris Shane A, Karpe Fredrik, Olsson Tommy, Storbeck Karl-Heinz, Micklesfield Lisa K.
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
Do sex hormone-binding globulin and testosterone levels affect type 2 diabetes risk differently in middle-aged African women based on HIV and menopausal status?
Conclusion
Midlife African women living with HIV have higher SHBG and lower testosterone levels, which may protect against type 2 diabetes.
Supporting Evidence
- SHBG levels were higher in postmenopausal women living with HIV compared to those without.
- Total and free testosterone levels were lower in postmenopausal women living with HIV.
- SHBG was positively associated with insulin sensitivity measures.
- The relationship between SHBG and insulin sensitivity was stronger in premenopausal women.
Takeaway
This study found that women with HIV have different hormone levels that might help protect them from diabetes compared to those without HIV.
Methodology
Cross-sectional observational study measuring hormone levels, body composition, and insulin sensitivity in premenopausal and postmenopausal women.
Potential Biases
Potential selection bias due to the specific population studied.
Limitations
The study is cross-sectional, limiting causal inferences.
Participant Demographics
Middle-aged Black South African women, both premenopausal and postmenopausal, with and without HIV.
Statistical Information
P-Value
p<0.023, p<0.011, p=0.043, p=0.021, p=0.015
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website