Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer
1999
Calmodulin-dependent protein kinase III in breast cancer
publication
Author Information
Author(s): Parmer T G, Ward M D, Yurkow E J, Vyas V H, Kearney T J, Hait W N
Primary Institution: University of Medicine and Dentistry of New Jersey
Hypothesis
The activity of CaM kinase III is selectively activated in proliferating cells and may play a significant role in breast cancer.
Conclusion
CaM kinase III is constitutively activated in human breast cancer and is regulated by breast cancer mitogens.
Supporting Evidence
- The specific activity of CaM kinase III was higher in breast cancer cell lines compared to normal tissue.
- CaM kinase III activity was regulated by breast cancer mitogens.
- Inhibition of CaM kinase III blocked cell proliferation induced by growth factors.
Takeaway
This study found that a specific protein involved in cell growth is more active in breast cancer cells, which might help them grow faster.
Methodology
The activity of CaM kinase III was measured in human breast cancer cell lines and fresh surgical specimens.
Digital Object Identifier (DOI)
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