HPV Variations and Cervical Dysplasia in North Dakota and Minnesota
Author Information
Author(s): Balakrishnan Lata, Clauson Ryan, Weiland Timothy, Bianco Michelle, Milavetz Barry
Primary Institution: University of North Dakota
Hypothesis
The increased incidence of high-grade dysplasia might be a result of differences in the high-risk HPV types responsible for the infections.
Conclusion
The presence of HPV types 16, 18, and 31 in triply infected samples may be responsible for the higher percentage of high-grade dysplasia in Roseau, MN compared to Grand Forks, ND.
Supporting Evidence
- 41% of samples from Roseau were triply infected with HPV types 16, 18, and 31.
- 12% of samples from Grand Forks were triply infected with HPV types 16, 18, and 31.
- High-grade dysplasia was approximately twice as high in Roseau compared to Grand Forks.
Takeaway
This study looked at cervical tissue samples to see how different types of HPV might cause more serious health problems in one area compared to another.
Methodology
Formaldehyde-fixed paraffin-embedded cervical tissue samples were analyzed using polymerase chain reaction (PCR) to detect HPV types 16, 18, and 31.
Limitations
The study was limited by the small sample size and the specific HPV types analyzed.
Statistical Information
P-Value
p < 0.004
Digital Object Identifier (DOI)
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