Structural and functional aspects of platelet-derived growth factor
1988
Understanding Platelet-Derived Growth Factor (PDGF)
publication
Author Information
Author(s): C.-H. Heldin, A. Hammacher, M. Nister, B. Westermark
Primary Institution: Ludwig Institute for Cancer Research and Department of Pathology, University Hospital, Uppsala, Sweden
Hypothesis
PDGF may have wider functions in mediating cell proliferation in various physiological and pathological conditions.
Conclusion
PDGF production is common in both normal and transformed cells, suggesting its role in autocrine and paracrine stimulation of cell growth.
Supporting Evidence
- PDGF is produced by various normal and transformed cell types.
- Different dimeric forms of PDGF have distinct functional effects.
- PDGF is a major mitogen for connective tissue and glial cells.
Takeaway
PDGF is a protein that helps cells grow and heal, and it is made by many different types of cells in the body.
Methodology
The review focuses on structural and functional aspects of PDGF-like factors and their involvement in cell growth stimulation.
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