Customized Prednisolone Gel Tablets for Veterinary Use
Author Information
Author(s): Tihhonova Marina, Meos Andres, Airaksinen Sari, Aruväli Jaan, Sandler Topelius Niklas, Heinämäki Jyrki, Paaver Urve
Primary Institution: University of Tartu
Hypothesis
The study investigates the feasibility of automated extrusion-based material deposition technology in preparing customized prednisolone-loaded gel tablets for veterinary applications.
Conclusion
Automated extrusion-based material deposition is a feasible method for the rapid preparation of gel tablets intended for veterinary applications.
Supporting Evidence
- The gel tablets showed a uniform round shape with a smooth outer surface.
- More than 70% of the drug load was released within 30 minutes in the dissolution tests.
- The content of prednisolone remained stable for at least 3 months when stored in a refrigerator.
Takeaway
Scientists are making special medicine tablets for pets that are easy to chew and can be made quickly using a new printing method.
Methodology
The study used automated extrusion-based material deposition to prepare gel tablets with varying prednisolone loads and conducted in vitro dissolution tests.
Limitations
The study had a small sample size and short duration of stability testing, and the findings may not be generalizable to other APIs.
Digital Object Identifier (DOI)
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