Intranasal Delivery for Treating Neurodegenerative Diseases
Author Information
Author(s): Leah R. Hanson, William H. Frey II
Primary Institution: Alzheimer's Research Center at Regions Hospital, HealthPartners Research Foundation
Hypothesis
Can intranasal delivery effectively bypass the blood-brain barrier to treat neurodegenerative diseases?
Conclusion
Intranasal delivery is a promising noninvasive method that can improve memory and potentially revolutionize the treatment of Alzheimer's disease and other neurodegenerative disorders.
Supporting Evidence
- Intranasal delivery allows drugs that do not cross the blood-brain barrier to be delivered to the central nervous system within minutes.
- Researchers have reversed neurodegeneration and rescued memory in a transgenic mouse model of Alzheimer's disease using intranasal delivery.
- Intranasal insulin improves memory, attention, and functioning in patients with Alzheimer's disease.
Takeaway
Using a nose spray can help deliver medicine directly to the brain, which can help people with memory problems like Alzheimer's.
Methodology
The study reviews the effectiveness of intranasal delivery methods for various therapeutics targeting the central nervous system.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website