Markers for Early Diagnosis of Hemorrhagic Shock and Encephalopathy Syndrome
Author Information
Author(s): Rinka Hiroshi, Yoshida Takeshi, Kubota Tetsushi, Tsuruwa Miho, Fuke Akihiro, Yoshimoto Akira, Kan Masanori, Miyazaki Dai, Arimoto Hideki, Miyaichi Toshinori, Kaji Arito, Miyamoto Satoru, Kuki Ichiro, Shiomi Masashi
Primary Institution: Emergency and Critical Care Medical Center, Osaka City General Hospital, Osaka, Japan
Hypothesis
Can specific clinical and laboratory markers be identified for the early diagnosis of hemorrhagic shock and encephalopathy syndrome (HSES) in children?
Conclusion
Elevated liver enzymes and creatine kinase, along with hypotension and metabolic acidosis, are useful markers for an early diagnosis of HSES.
Supporting Evidence
- All 8 patients had normal platelet counts and blood pressure upon admission.
- Five patients had a history of diarrhea and/or vomiting.
- Seven patients had elevated liver enzymes and creatine kinase upon admission.
- All patients exhibited severe metabolic acidosis with a median base excess of -10.3 mmol/L upon admission.
- Three patients survived, while five patients died.
Takeaway
Doctors can tell if a child has a serious illness called HSES by looking for certain signs like high liver enzymes and low blood pressure.
Methodology
The study reviewed clinical, biological, and radiological findings of 8 patients who met the HSES criteria.
Limitations
The study had a small sample size of only 8 patients.
Participant Demographics
Patients aged 4 months to 9 years, with a median age of 1.6 years.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website