Why treatment fails in type 2 diabetes
2008
Why Treatment Fails in Type 2 Diabetes
publication
Evidence: moderate
Author Information
Author(s): Anders Rosengren, Xingjun Jing, Lena Eliasson, Erik Renström
Primary Institution: Lund University Diabetes Centre, Malmö, Sweden
Hypothesis
Can the secondary failure of sulfonylurea treatment in type 2 diabetes be reversed?
Conclusion
The study found that the decreased capacity for insulin secretion due to sulfonylurea treatment is reversible.
Supporting Evidence
- The study suggests that insulin secretion can be restored after stopping sulfonylurea treatment.
- Previous assumptions about beta-cell death due to sulfonylurea treatment may need to be reconsidered.
- The findings indicate a temporary impairment rather than permanent damage to beta-cells.
Takeaway
This study shows that if a diabetes treatment stops working, it might start working again after a break.
Methodology
The authors implanted slow-release pellets of sulfonylurea in mice to study insulin secretion.
Limitations
The study's findings in mice may not fully apply to humans, as the onset of secondary failure appears faster in mice.
Participant Demographics
Mice were used in the study.
Digital Object Identifier (DOI)
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