Meta-analysis of SUMO1
2008
Meta-analysis of SUMO1
Sample size: 15
publication
Evidence: moderate
Author Information
Author(s): Brian J Wilson
Primary Institution: McGill University Health Centre
Hypothesis
What are the pathway partners of SUMO1?
Conclusion
The study suggests that DAD1 and DEK are new pathway partners of SUMO1 based on co-expression analysis.
Supporting Evidence
- DAD1 was co-expressed with SUMO1 in 67% of the studies analyzed.
- DEK was co-expressed with SUMO1 in 53% of the studies analyzed.
- The study identified over 400 consistently co-expressed genes with SUMO1.
Takeaway
The study looked at many studies to find out which genes work with SUMO1, and found two new ones that might help it do its job.
Methodology
An in-silico co-expression meta-analysis of SUMO1 was performed using data from the Oncomine database.
Potential Biases
The meta-analysis technique has a high false-negative rate.
Limitations
The findings are predictive and need to be confirmed by future experiments.
Digital Object Identifier (DOI)
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