AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma
2001
Blocking a receptor reduces brain tumor growth
publication
Evidence: moderate
Author Information
Author(s): Rivera E, Arrieta O, Guevara P, Duarte-Rojo A, Sotelo J
Primary Institution: Neuroimmunology Unit, National Institute of Neurology and Neurosurgery of Mexico
Hypothesis
Does blocking the AT1 receptor reduce the growth of glioma cells?
Conclusion
Blocking the AT1 receptor with Losartan significantly reduces the growth of glioma cells.
Supporting Evidence
- Losartan induced a 79% reduction of tumor volume.
- There was a significant decrease in vascular density, mitotic index, and cell proliferation.
Takeaway
A medicine called Losartan can help shrink brain tumors by blocking a specific receptor.
Methodology
The study examined the effect of Losartan on C6 glioma cells in rats.
Participant Demographics
C6 glioma cells in rats
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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