Engineering and Applications of Fungal Laccases for Organic Synthesis
Author Information
Author(s): Kunamneni Adinarayana, Camarero Susana, García-Burgos Carlos, Plou Francisco J, Ballesteros Antonio, Alcalde Miguel
Primary Institution: Departamento de Biocatálisis, Instituto de Catálisis y Petroleoquímica, CSIC, Madrid, Spain
Conclusion
Fungal laccases are versatile enzymes that can be engineered for various applications in organic synthesis, offering a green alternative to traditional chemical methods.
Supporting Evidence
- Laccases can oxidize a wide range of substrates, making them useful in various biotechnological applications.
- Fungal laccases can be engineered to improve their stability and activity for specific industrial processes.
- Laccase-mediator systems enhance the substrate range and efficiency of laccases in organic synthesis.
Takeaway
Laccases are special proteins from fungi that help turn certain chemicals into new products, making them useful for creating things like medicines and biodegradable materials.
Methodology
The review discusses the biochemical properties of laccases, their applications in organic synthesis, and the engineering of these enzymes through rational design and directed evolution.
Limitations
The use of laccase-mediator systems can be limited by the cost and potential toxicity of the mediators, as well as the need for large quantities of enzymes for industrial applications.
Digital Object Identifier (DOI)
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