Keishibukuryogan Reduces Kidney Damage in Early Renal Failure
Author Information
Author(s): Takako Nakagawa, Izumi Tashiro, Makoto Fujimoto, Michiko Jo, Shinya Sakai, Hiroshi Oka, Hirozo Goto, Yutaka Shimada, Naotoshi Shibahara
Primary Institution: University of Toyama
Hypothesis
Does keishibukuryogan have beneficial effects on renal function in the early stage of renal failure?
Conclusion
Keishibukuryogan treatment at the early stage of renal failure can slow down the progression of chronic renal failure.
Supporting Evidence
- 3% keishibukuryogan significantly reduced serum urea nitrogen levels compared to the control group.
- Gene expressions related to kidney damage were significantly suppressed by 3% keishibukuryogan treatment.
- Histological examination showed no severe changes in the kidneys of treated rats.
Takeaway
Keishibukuryogan is a traditional herbal medicine that helps protect the kidneys from damage when they are not working well.
Methodology
Rats underwent 5/6 nephrectomy and were treated with keishibukuryogan for 4 weeks; kidney function and gene expressions were analyzed.
Limitations
The study was conducted on rats, and further clinical trials are needed to confirm the findings in humans.
Participant Demographics
Male Wistar rats, aged 6 weeks at the start of the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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