Antioxidant and Antiproliferative Activities of Heterofucans from Sargassum filipendula
Author Information
Author(s): Leandro Silva Costa, Fidelis Gabriel Pereira, Telles Cinthia Beatrice Silva, Dantas-Santos Nednaldo, Camara Rafael Barros Gomes, Cordeiro Sara Lima, Pereira Costa Mariana Santana Santos, Almeida-Lima Jailma, Melo-Silveira Raniere Fagundes, Oliveira Ruth Medeiros, Albuquerque Ivan Rui Lopes, Andrade Giulianna Paiva Viana, Rocha Hugo Alexandre Oliveira
Primary Institution: Universidade Federal do Rio Grande do Norte (UFRN)
Hypothesis
The study aims to evaluate the biological activities of sulfated polysaccharides obtained from Sargassum filipendula.
Conclusion
The study found that the polysaccharides from Sargassum filipendula exhibited significant antioxidant and antiproliferative activities.
Supporting Evidence
- Five different heterofucans were obtained from Sargassum filipendula.
- SF-1.0v showed the most significant antioxidant potential with 90.7 ascorbic acid equivalents.
- The strongest antiproliferative activity was observed in HeLa cells with IC50 values of 15.69 μM for SF-1.0v.
- None of the polysaccharides showed anticoagulant activity in PT and aPTT tests.
- All heterofucans exhibited significant dose-dependent ferrous chelating capacity.
Takeaway
Researchers studied a type of seaweed and found that it has special sugars that can help fight cancer and protect against damage from bad chemicals.
Methodology
The study involved extracting polysaccharides from Sargassum filipendula and testing their antioxidant and antiproliferative activities using various assays.
Limitations
Further purification steps and additional studies on structural features and in vivo experiments are needed.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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