Impact of C3-epi-D3 on Metabolic Disorders in Type 2 Diabetes
Author Information
Author(s): Chen Xiaohong, Peng Bi, Ye Wenchun, Wu Bitao, Yang Qiang, Tang Jie, Yang Yuwei
Primary Institution: Mianyang Central Hospital, Affiliated to School of Medicine, University of Electronic Science and Technology of China
Hypothesis
Does C3-epi-D3 affect metabolic disorders in patients with type 2 diabetes mellitus?
Conclusion
C3-epi-D3 levels and proportions have a seasonal impact on metabolic disorders in type 2 diabetes patients, particularly related to chronic kidney disease.
Supporting Evidence
- C3-epi-D3 levels showed significant seasonal differences.
- Independent association between %C3-epi-D3 and CKD severity was observed.
- C3-epi-D3 levels correlated with calcium-phosphorus metabolism in autumn and winter.
- Age and seasonal variations were noted in C3-epi-D3 levels.
- Dyslipidemias showed no evident correlation with C3-epi-D3 levels.
Takeaway
This study found that the levels of a vitamin D-related substance, C3-epi-D3, change with the seasons and can affect kidney health in diabetes patients.
Methodology
1222 patients with type 2 diabetes were followed for 3 to 6 months, measuring kidney biomarkers, lipids, electrolytes, and 25-OHD metabolites.
Potential Biases
Potential bias due to exclusion criteria and specific patient demographics.
Limitations
Findings may not be generalizable to other populations or ethnicities, and the study lacks regional variation.
Participant Demographics
735 males and 487 females, aged 45 to over 90 years.
Statistical Information
P-Value
P<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website