Prognostic Significance of uPA and PAI-1 in Breast Cancer
Author Information
Author(s): Philippe Leissner, Thibault Verjat, Thomas Bachelot, Malick Paye, Alexander Krause, Alain Puisieux, Bruno Mougin
Primary Institution: bioMérieux SA, Grenoble, France
Hypothesis
The study investigates the prognostic value of uPA and PAI-1 mRNA expression in lymph node- and hormone receptor-positive breast cancer.
Conclusion
High PAI-1 mRNA expression is a strong and independent unfavorable prognostic factor for metastases and breast cancer specific survival.
Supporting Evidence
- High levels of PAI-1 mRNA were associated with significantly shorter metastasis-free survival.
- In Cox multivariate analysis, PAI-1 mRNA level was the strongest prognostic factor for metastasis-free survival.
- uPA expression did not show significant independent prognostic value.
Takeaway
This study found that if a patient has high levels of a certain marker (PAI-1) in their breast cancer, they might have a worse chance of surviving the disease.
Methodology
The study used real-time quantitative RT-PCR to measure mRNA levels of uPA and PAI-1 in tumor samples from 87 patients.
Potential Biases
Potential bias due to the small sample size and specific patient selection.
Limitations
The study is retrospective and may have selection bias due to the specific population of hormone receptor- and node-positive breast cancer patients.
Participant Demographics
Median age of participants was 54 years, with a range from 29 to 74 years.
Statistical Information
P-Value
p < 0.0001 for PAI-1 and MFS, p = 0.0002 for PAI-1 and BCS.
Confidence Interval
95% CI for PAI-1 HR = 10.12 (3.03–33.76) for MFS.
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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