Recent advances in the tumour biology of the GPI-anchored carcinoembryonic antigen family members CEACAM5 and CEACAM6
2007
Updates on CEACAM5 and CEACAM6 in Cancer
publication
Evidence: moderate
Author Information
Author(s): Chan C.H.F., Stanners C.P.
Primary Institution: McGill University
Hypothesis
CEACAM5 and CEACAM6 play significant roles in tumorigenesis and may serve as targets for cancer therapies.
Conclusion
CEACAM5 and CEACAM6 are overexpressed in many cancers and represent promising targets for novel cancer therapies.
Supporting Evidence
- CEACAM5 and CEACAM6 are overexpressed in as many as 70% of all human tumors.
- Overexpression of CEACAM5 and CEACAM6 is often associated with poor prognosis.
- These proteins have various tumorigenic effects, including inhibiting cell death and promoting metastasis.
Takeaway
CEACAM5 and CEACAM6 are proteins that can help cancer cells grow and spread, and scientists think they can be used to create new cancer treatments.
Limitations
The study does not specify limitations but notes the overwhelming volume of literature may dilute significant findings.
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