Antioxidant Effects of Podophyllum hexandrum Extract on Kidney and Lung Damage
Author Information
Author(s): Ganie Showkat Ahmad, Haq Ehtishamul, Hamid Abid, Qurishi Yasrib, Mahmood Zahid, Zargar Bilal Ahmad, Masood Akbar, Zargar Mohmmad Afzal
Primary Institution: University of Kashmir
Hypothesis
The aqueous extract of Podophyllum hexandrum can protect kidney and lung tissues from carbon tetrachloride-induced oxidative stress.
Conclusion
The study demonstrated that the aqueous extract of Podophyllum hexandrum could protect kidney and lung tissue against oxidative stress caused by carbon tetrachloride.
Supporting Evidence
- The extract showed strong superoxide and hydrogen peroxide radical scavenging activity.
- CCl4 caused significant increases in TBARS levels and decreases in antioxidant enzyme levels.
- Pretreatment with the extract prevented alterations in antioxidant enzyme activities.
Takeaway
This study found that a plant extract can help protect the kidneys and lungs from damage caused by a harmful chemical.
Methodology
The study involved 36 albino rats divided into six groups, with some receiving carbon tetrachloride and others receiving varying doses of the plant extract or vitamin E, followed by assessment of antioxidant enzyme activities and tissue damage.
Limitations
The study was limited to animal models and may not directly translate to human outcomes.
Participant Demographics
Adult male albino rats of Wistar strain, weighing 200-250 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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