Neutrophil Percentage-to-Albumin Ratio and Stroke Risk
Author Information
Author(s): Xu Shuying, Sun Yiyan, Zhang Siyao, Peng Yongjun, Dai Dechun, Zhao Leiyong
Primary Institution: Kunshan Hospital of Traditional Chinese Medicine
Hypothesis
This research aims to examine the association between neutrophil percentage-to-albumin ratio (NPAR) and stroke.
Conclusion
The study found a nonlinear positive association between NPAR and stroke risk, indicating that higher NPAR increases the likelihood of stroke.
Supporting Evidence
- NPAR was positively associated with stroke with an odds ratio of 1.09 after adjusting for confounders.
- The relationship between NPAR and stroke was nonlinear, with an inflection point at NPAR = 13.81.
- Stratified analyses showed a positive correlation between NPAR and stroke risk in both men and women.
Takeaway
This study shows that if you have a higher level of a certain blood marker called NPAR, you might be more likely to have a stroke.
Methodology
The study used logistic regression and restricted cubic splines to analyze data from the NHANES database.
Potential Biases
Residual confounding may still affect the observed association between NPAR and stroke.
Limitations
The cross-sectional design limits the ability to establish causality, and the results may not be generalizable to other populations.
Participant Demographics
The mean age of participants was 47.08 years, with 51.74% being female.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI: 1.05–1.12
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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