Significance of Sialyl Lewis x in Advanced Gastric Carcinoma
Author Information
Author(s): Futamura N, Nakamura S, Tatematsu M, Yamamura Y, Kannagi R, Hirose H
Primary Institution: Gifu University School of Medicine
Hypothesis
The study investigates the clinicopathologic significance of sialyl Lewis x expression in patients with advanced gastric carcinoma.
Conclusion
Sialyl Lewis x expression is associated with worse prognoses and higher rates of metastasis in patients with differentiated gastric carcinoma.
Supporting Evidence
- SLX was expressed in 135 of 245 patients (55%).
- 75% of patients with differentiated carcinoma expressed SLX.
- 44% of patients with undifferentiated carcinoma expressed SLX.
- SLX-positive patients with differentiated carcinoma had higher rates of lymph node metastasis.
- Prognoses were better in SLX-negative patients than in SLX-positive patients.
Takeaway
This study found that a specific marker, sialyl Lewis x, can help doctors understand how serious a patient's stomach cancer is, especially in certain types of cancer.
Methodology
Immunohistochemical examination of sialyl Lewis x expression in gastric carcinoma patients.
Participant Demographics
245 patients with advanced gastric carcinoma, classified into differentiated (91) and undifferentiated (154) types.
Statistical Information
P-Value
p<0.0001, p=0.0065, p=0.028, p=0.019
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website