EGFR and Her-2 in Oral Cancer
Author Information
Author(s): Chen I-H, Chang J T, Liao C-T, Wang H-M, Hsieh L-L, Cheng A-J
Primary Institution: Chang Gung Memorial Hospital, Taoyuan, Taiwan
Hypothesis
Does the expression of EGFR and Her-2 correlate with clinicopathological variables and prognosis in oral cavity cancer?
Conclusion
EGFR overexpression is significantly associated with poor survival in oral cancer patients, while Her-2 does not show a similar correlation.
Supporting Evidence
- EGFR was overexpressed in 58% of cancer tissues.
- Her-2 was overexpressed in 41% of cancer tissues.
- High levels of EGFR were associated with poor survival outcomes.
- Significant correlations were found between EGFR expression and various clinicopathological parameters.
Takeaway
This study looked at two proteins, EGFR and Her-2, in patients with mouth cancer to see if they could help predict how well patients would do. They found that high levels of EGFR were linked to worse outcomes.
Methodology
The study involved 59 patients with oral cancer, analyzing EGFR and Her-2 expression in paired normal and cancerous tissues using ELISA.
Potential Biases
Potential bias due to the subjective nature of histological grading and the specific population studied.
Limitations
The study focused only on male patients and may not represent the entire population of oral cancer patients.
Participant Demographics
All participants were male, with a median age of 48 years; 90% were smokers and betel quid chewers.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI=1.07–32.31
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website