Biological Aging and Its Role in Depression and Mortality
Author Information
Author(s): Wei Kai, Chen Xiaotong
Primary Institution: Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China; Jing’an District Centre Hospital of Shanghai, Shanghai, Shanghai, China
Hypothesis
Biological aging mediates the relationship between depression and mortality.
Conclusion
Accelerated aging partially mediates the association between major depression and all-cause mortality in US populations.
Supporting Evidence
- Major depression is positively associated with biological aging acceleration.
- The mediation proportion of biological aging acceleration in associations of major depression with all-cause mortality were significant.
- Similar results were found in the Health and Retirement Study.
Takeaway
If someone is very sad for a long time, it can make them age faster and might lead to them not living as long.
Methodology
Longitudinal data analysis using the National Health and Nutrition Examination Survey and various aging measures.
Participant Demographics
Participants were aged 20 years and older from the US population.
Statistical Information
P-Value
p=0.0005, p=0.0006, p=0.0004
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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