Neighborhood Disadvantage and Plasma Biomarkers' Impact on Cognition
Author Information
Author(s): Fan Erica, Royse Sarah, Reese Alexandria, Karikari Thomas, Pascoal Tharick, Shaaban C, Villemagne Victor, Cohen Ann
Primary Institution: University of Pittsburgh
Hypothesis
Does neighborhood disadvantage modify the association of plasma biomarkers with cognition in diverse adults?
Conclusion
The study found that the relationship between plasma biomarkers and cognition varies based on neighborhood conditions.
Supporting Evidence
- Higher neighborhood disadvantage was associated with worse cognition.
- Interactions between neighborhood disadvantage and plasma biomarkers were significant for immediate and delayed word recall.
- In low neighborhood disadvantage, higher pTau217 was linked to worse recall scores.
Takeaway
This study looked at how where people live affects the relationship between certain blood markers and their thinking skills.
Methodology
The study used adjusted linear models to analyze the association of plasma biomarkers with cognition, considering neighborhood disadvantage measured by the area deprivation index.
Participant Demographics
Diverse adults aged 50 and older.
Statistical Information
P-Value
p=0.005
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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