No HPV DNA Found in Breast Cancer
Author Information
Author(s): D. Wredel, Y.A. Luqmani, R.C. Coombes, K.H. Vousden
Primary Institution: Ludwig Institute for Cancer Research
Hypothesis
Is HPV involved in the pathogenesis of breast cancer?
Conclusion
This study shows that HPV types 16 and 18 are absent from a large series of breast cancers.
Supporting Evidence
- DNA from 95 primary breast cancers was tested for HPV DNA.
- 80 samples were analyzed after excluding those with inadequate material.
- No breast cancer sample containing amplifiable DNA was positive for HPV 16 or 18.
Takeaway
The researchers looked for HPV DNA in breast cancer samples and found none, suggesting HPV isn't a cause of breast cancer.
Methodology
DNA from 95 primary breast cancers was extracted and tested for HPV DNA using PCR.
Limitations
The study only tested for HPV types 16 and 18 and did not rule out other HPV types.
Participant Demographics
{"age_range":"29-76","mean_age":54,"menopausal_status":{"pre":25,"post":41,"peri":5,"not_known":9},"oestrogen_receptor_status":{"positive":42,"negative":23,"not_classified":15}}
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