Homocysteine and Lipid Profile in Children with Juvenile Idiopathic Arthritis
Author Information
Author(s): Gonçalves Marcela, D'Almeida Vânia, Guerra-Shinohara Elvira M, Galdieri Luciano C, Len Claudio A, Hilário Maria Odete E
Primary Institution: Universidade Federal de São Paulo (Unifesp)
Hypothesis
The study aims to evaluate plasma homocysteine concentration in patients with juvenile idiopathic arthritis and its correlation with methotrexate therapy, serum folate and B12 vitamin, and hyperlipidemia.
Conclusion
JIA patients do not present significant increased concentration of homocysteine despite the use of methotrexate, probably due to the folate supplementation.
Supporting Evidence
- The mean plasma homocysteine concentration was 9.3 μmol/L in JIA patients and 8.9 μmol/L in healthy controls.
- Higher concentration of homocysteine was observed in the subgroup of 13 – 18 years.
- Normal values of vitamin B12 were detected in both patients and controls.
- Serum folate concentration was higher in patients compared to controls.
Takeaway
The study looked at kids with a type of arthritis and found that their homocysteine levels were normal, likely because they were taking vitamins.
Methodology
A cross-sectional study involving 51 children with JIA and 52 healthy controls, measuring various blood parameters.
Limitations
The study's data is not conclusive and suggests the need for multicentric studies with larger sample sizes.
Participant Demographics
51 children with JIA (37 females, mean age 11.3 years) and 52 healthy controls (42 females, mean age 12.5 years).
Statistical Information
P-Value
0.615
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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