Mechanism of Wound-Healing Activity of Hippophae rhamnoides L. Leaf Extract in Experimental Burns
2011

Wound Healing Effects of Sea Buckthorn Leaf Extract

Sample size: 6 publication Evidence: moderate

Author Information

Author(s): Nitin K. Upadhyay, Ratan Kumar, M. S. Siddiqui, Asheesh Gupta

Primary Institution: Defence Institute of Physiology and Allied Science, DRDO, Delhi, India

Hypothesis

The study investigates the healing efficacy of Sea buckthorn leaf extract on burn wounds in rats.

Conclusion

The study concludes that Sea buckthorn leaf extract significantly promotes wound healing in burn wounds.

Supporting Evidence

  • The SBT-treated group showed faster reduction in wound area compared to control and SSD-treated groups.
  • Topical application of SBT increased collagen synthesis and stabilization at the wound site.
  • Histological examinations confirmed the healing efficacy of SBT leaf extract.

Takeaway

This study shows that a special plant extract can help heal burns faster and better.

Methodology

The study used male Sprague-Dawley rats with burn wounds treated with different concentrations of Sea buckthorn leaf extract and compared the results with control groups.

Limitations

The study was conducted on a small sample size and only in rats, which may limit the generalizability of the results to humans.

Participant Demographics

Male Sprague-Dawley rats, weighing 180 ± 20 g.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1093/ecam/nep189

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