Chance and Familial Colorectal Cancer
Author Information
Author(s): Katballe N, Bentzen S M, Christensen M, Wikman F P, Ørntoft T, Laurberg S
Primary Institution: Aarhus University Hospital
Hypothesis
What role does chance play in the familial aggregation of colorectal cancer?
Conclusion
The study suggests that chance clustering accounts for very few families meeting the criteria for hereditary non-polyposis colorectal cancer.
Supporting Evidence
- The study involved 77 colorectal cancer patients.
- Mathematical modeling was used to analyze population age-incidence data.
- Only 1 family is expected to meet the Amsterdam criteria due to chance.
Takeaway
The researchers looked at families with colorectal cancer and found that only a few of them might have cancer clustering just by chance.
Methodology
A prospective population-based study recorded family trees of colorectal cancer patients and used mathematical modeling.
Participant Demographics
Colorectal cancer patients younger than 50 years of age.
Statistical Information
Confidence Interval
95% confidence limits 0 and 3
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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