Retinal Changes in Myopic Eyes
Author Information
Author(s): Zeng Chen, Tang Chong, Tan Yixin, Liu Juxian, Shi Kai, Li Qi
Primary Institution: Chongqing Key Laboratory of Prevention and Treatment on Major Blinding Diseases, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Hypothesis
This study aimed to comprehensively explore the thickness and topographic distributions of retinal vessel alterations of different myopic eyes by using swept-source OCT angiography (SS-OCTA).
Conclusion
Retinal vessel microstructure was more easily affected in highly myopic eyes, especially in superficial blood vessels, and compartmental analysis showed that alterations in nasal peripapillary sectors were more evident.
Supporting Evidence
- High myopes exhibited lower vessel density and flow area, especially in the superficial layer.
- Alterations in nasal peripapillary sectors were more evident in high myopes.
- Thickness of the whole retina and RNFL were negatively correlated with AL/CR ratio in non-high myopes.
- Vessel density and flow area of several layers were positively correlated with AL/CR ratio in non-high myopes.
- Statistical significance was found in comparisons of ocular parameters between myopic groups.
Takeaway
This study looked at how myopia affects the blood vessels in the eyes, finding that more severe myopia leads to more noticeable changes in the blood vessels.
Methodology
This observational cross-sectional study included 100 myopic patients who underwent ocular examinations and SS-OCTA imaging to measure retinal parameters.
Potential Biases
Potential confounding factors such as IOP and ACD could influence the results.
Limitations
The study's participants were mostly young, limiting representativeness, and the sample size was limited.
Participant Demographics
54 males and 46 females, average age 21.04 years.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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