Frequent p53 mutation in brain (fetal)-type glycogen phosphorylase positive foci adjacent to human ‘de novo’ colorectal carcinomas
2001
Frequent p53 Mutation in Colorectal Carcinomas
Sample size: 17
publication
Evidence: moderate
Author Information
Author(s): Shimada S, Shiomori K, Tashima S, Tsuruta J, Ogawa M
Primary Institution: Kumamoto University School of Medicine
Hypothesis
The study investigates genetic alterations in brain (fetal)-type glycogen phosphorylase positive foci in relation to 'de novo' colorectal carcinogenesis.
Conclusion
The study found that BGP foci in colorectal transitional mucosa frequently exhibit p53 gene mutations, suggesting they may be premalignant.
Supporting Evidence
- The study selected 17 colorectal carcinomas without adenoma components.
- The PCNA labelling index was significantly higher in BGP foci compared to BGP negative mucosa.
- p53 mutations were found in 8 of the carcinomas studied.
- No K-ras mutations were detected in the samples.
Takeaway
The researchers looked at some areas in the gut that might turn into cancer and found that they often had changes in a gene called p53.
Methodology
The study involved examining 17 colorectal carcinomas for p53 and K-ras mutations and measuring the PCNA labelling index.
Statistical Information
P-Value
P< 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website