Triglyceride-glucose index and stroke risk in older Chinese adults
Author Information
Author(s): Li Xu, Hu Jia-Guang, Liao Qian, Wu Ying, Huo Rong-Rui
Primary Institution: Guangxi Health Commission Key Laboratory of Clinical Biotechnology, Liuzhou People’s Hospital, Liuzhou, China
Hypothesis
Does the triglyceride-glucose index mediate the association between residual cholesterol and stroke risk in middle-aged and older adults in China?
Conclusion
The triglyceride-glucose index completely mediates the association between residual cholesterol and stroke risk among middle-aged and older Chinese adults.
Supporting Evidence
- A one SD increase in residual cholesterol was associated with an elevated risk of stroke (HR, 1.09; 95% CI, 1.02–1.16).
- During a median follow-up of 7.1 years, 734 (7.0%) participants experienced a stroke.
- TyG index mediated the association between residual cholesterol and stroke (b, −0.16; 95% CI, −0.30 to −0.03).
- Subgroup analyses showed consistent results across different demographics.
Takeaway
This study found that higher levels of certain fats in the blood can lead to a higher chance of having a stroke, especially in older people.
Methodology
This is a prospective cohort study that followed 10,569 middle-aged and older adults in China from 2011 to 2018, analyzing the relationship between residual cholesterol, triglyceride-glucose index, and stroke risk.
Potential Biases
Potential residual confounding due to unmeasured factors like diet and physical activity.
Limitations
The study's observational nature limits causal inferences, and self-reported stroke diagnoses may introduce bias.
Participant Demographics
Participants were middle-aged and older adults, with a mean age of 59.01 years, and included 47.1% men.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI, 1.02–1.16
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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