Pilot Study on Pediatric Anesthesia Safety in Asia
Author Information
Author(s): Obara Soichiro, Bong Choon Looi, Ustalar Ozgen Zehra Serpil, Abbasi Shemila, Rai Ekta, Villa Evangeline K., Ramlan Andi Ade W., Zahra Raihanita, Kapuangan Christopher, Ferdiana Komang Ayu, Shariffuddin Ina Ismiarti, Yuen Vivian, Varghese Elsa, Tan Josephine S. K., Kuratani Norifumi
Primary Institution: Teikyo University Graduate School of Public Health
Hypothesis
The PEACH in Asia pilot study aimed to test the feasibility of a standardized protocol for investigating severe critical events in pediatric anesthesia practices across Asia.
Conclusion
The pilot study successfully validated a protocol for investigating severe critical events in pediatric anesthesia across Asia.
Supporting Evidence
- The pilot study enrolled 330 patients, with a severe critical event incidence of 12.4%.
- Respiratory events were observed in 7.0% of cases, and cardiovascular instability in 4.9%.
- The estimated sample size required for the main study is at least 10,958 patients.
Takeaway
This study looked at how safe anesthesia is for kids in Asia and found that there were some serious problems, but they also figured out a way to study it better in the future.
Methodology
This multicenter pilot study involved ten institutions across nine Asian countries, collecting data on severe critical events using standardized definitions.
Potential Biases
The necessity for informed consent in some regions may introduce selection bias.
Limitations
The short recruitment period and variability in patient enrollment across institutions limit the generalizability of the findings.
Participant Demographics
Of the 330 patients, 290 (87.9%) were of Asian descent, and 64 (19.4%) had an ASA physical status of III or higher.
Statistical Information
P-Value
0.006
Confidence Interval
95% CI: 9.2–16.4
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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