Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation
2000
DNA-PK Activity and Low-Dose Radiation Sensitivity in Cancer Cells
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): Vaganay-Juéry S, Muller C, Marangoni E, Abdulkarim B, Deutsch E, Lambin P, Calsou P, Eschwege F, Salles B, Joiner M, Bourhis J
Primary Institution: Institut Gustave Roussy
Hypothesis
The study investigates the role of the DNA repair DNA-PK complex in low-dose hyper-radiosensitivity in human cancer cells.
Conclusion
The study found that low-dose irradiation decreases DNA-PK activity in cancer cells that are hypersensitive to radiation.
Supporting Evidence
- The study involved 10 human cancer cell lines.
- DNA-PK activity decreased in cells that were hypersensitive to low-dose radiation.
- The decrease in DNA-PK activity occurred within 2 hours after radiation exposure.
Takeaway
When cancer cells are exposed to a small amount of radiation, some of them become very sensitive and their DNA repair system doesn't work well.
Methodology
The activity of the DNA-PK complex was studied in 10 human cancer cell lines after exposure to low-dose irradiation.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website