Irritability in Children with Rasopathies
Author Information
Author(s): Serur Yaffa, Fuhrman Naomi, Russo Odeya, Green Tamar
Hypothesis
This study investigates the impact of Rasopathy status on the associations between irritability, emotional dysregulation-related disorders, and social skills impairments in children.
Conclusion
Children with Rasopathies exhibit higher irritability and distinct associations with ADHD symptoms and social skills impairments compared to typically developed children.
Supporting Evidence
- Children with Rasopathies exhibited higher irritability than typically developed children.
- Children with Noonan Syndrome showed a weaker association between irritability and ADHD symptoms compared to typically developed children.
- Children with Noonan Syndrome had a stronger association between irritability and social skills impairments compared to both typically developed and Neurofibromatosis type 1 groups.
Takeaway
Kids with certain genetic conditions are more irritable and have more trouble with social skills than kids without those conditions.
Methodology
Parent questionnaires were used to assess irritability and related symptoms while controlling for cognitive measures.
Participant Demographics
The sample included 174 children aged 4–17, with 98 females and 113 children diagnosed with Rasopathies.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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