Improved survival following surgery and radiation therapy for olfactory neuroblastoma
Author Information
Author(s): Mary E Platek, Mihai Merzianu, Terry L Mashtare, Saurin R Popat, Nestor R Rigual, Graham W Warren, Anurag K Singh
Primary Institution: Roswell Park Cancer Institute
Hypothesis
Does the addition of radiation therapy to surgery improve survival outcomes for patients with olfactory neuroblastoma?
Conclusion
Best survival results were obtained for surgery with radiotherapy.
Supporting Evidence
- Five year overall survival was 73% for surgery with radiotherapy.
- 68% survived five years with surgery only.
- 35% survived five years with radiotherapy only.
- 26% survived five years with neither surgery nor radiotherapy.
Takeaway
If you have a rare nose tumor called olfactory neuroblastoma, having surgery and radiation together helps you live longer than just having surgery or radiation alone.
Methodology
The SEER database was queried for olfactory neuroblastoma cases, and survival distributions were estimated using Kaplan-Meier and analyzed with Cox regression.
Potential Biases
There is a risk of selection bias as treatment decisions were based on clinical information not captured in the SEER database.
Limitations
Selection bias may affect the comparison between treatment groups due to unrecorded clinical factors influencing treatment decisions.
Participant Demographics
The majority of participants were white males aged between 40 and 70 years.
Statistical Information
P-Value
p < 0.01
Statistical Significance
p < 0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website