Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer
1999
No ATM Gene Mutations Found in Breast Cancer Cases
Sample size: 47
publication
Evidence: low
Author Information
Author(s): Bebb D G, Yu Z, Chen J, Telatar M, Gelmon K, Phillips N, Gatti R A, Glickman B W
Primary Institution: Centre for Environmental Health, Department of Biology, University of Victoria
Hypothesis
Is there an association between ATM mutations and sporadic breast cancer?
Conclusion
The study found no mutations in the ATM gene among the 47 women with sporadic breast cancer.
Supporting Evidence
- Epidemiological evidence suggests a link between ataxia telangiectasia and breast cancer risk.
- Previous studies did not confirm an association between ATM mutations and familial breast cancer.
Takeaway
The researchers looked for a specific gene mutation in women with breast cancer but didn't find any.
Methodology
Screening for ATM mutations in 47 women with sporadic breast cancer.
Participant Demographics
Women with later onset sporadic breast cancer.
Digital Object Identifier (DOI)
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