Homocysteine, Vitamin B12, and Folate Levels in Premature Coronary Artery Disease
Author Information
Author(s): Sadeghian Saeed, Fallahi Faramarz, Salarifar Mojtaba, Davoodi Gholamreza, Mahmoodian Mehran, Fallah Nader, Darvish Soodabeh, Karimi Abbasali
Primary Institution: Tehran Heart Center, Tehran University of Medical Sciences
Hypothesis
The study aims to assess the role of hyperhomocysteinemia, folate, and Vitamin B12 deficiency in the development of premature coronary artery disease.
Conclusion
Hyperhomocysteinemia is an independent risk factor for coronary artery disease in young patients, especially in men, and vitamin B12 deficiency is a preventable cause of hyperhomocysteinemia.
Supporting Evidence
- 43.1% of participants had coronary artery disease.
- 10.7% of the study group had folate deficiency.
- 26.6% had Vitamin B12 deficiency.
- Hyperhomocysteinemia was identified as an independent risk factor for premature CAD in males.
Takeaway
This study found that high levels of homocysteine can lead to heart problems in younger people, especially men, and that not getting enough vitamin B12 can make this worse.
Methodology
An analytical case-control study was performed on 294 individuals under 45 years who underwent selective coronary angiography.
Limitations
The smaller sample size of female participants limits the ability to evaluate the role of hyperhomocysteinemia in young females with CAD.
Participant Demographics
225 participants (179 males and 46 females) under 45 years old.
Statistical Information
P-Value
0.01
Confidence Interval
1.23 to 5.22
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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