Ondansetron and Dexamethasone for Chemotherapy Nausea
Author Information
Author(s): D.B. Smith, E.S. Newlands, O.W. Spruyt, R.H.J. Begent, G.J.S. Rustin, B. Mellor, K.D. Bagshawe
Primary Institution: Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross Hospital
Hypothesis
Does the combination of Ondansetron and dexamethasone provide better anti-emetic control for patients receiving chemotherapy than either drug alone?
Conclusion
The combination of Ondansetron and dexamethasone is effective in controlling nausea and vomiting in patients who did not respond to previous treatments.
Supporting Evidence
- 90% of patients who failed previous treatments responded to the combination therapy.
- 9 out of 14 patients had a complete response with no nausea or vomiting.
- The only side effect noted was mild headache in two patients.
Takeaway
This study found that giving two medicines together helped most patients feel better and not throw up during their cancer treatment.
Methodology
Patients received Ondansetron and dexamethasone for 5 days and their nausea and vomiting were recorded.
Limitations
The study had a small sample size and was not randomized.
Participant Demographics
Median age of participants was 28 years, with a range of 18-41 years.
Statistical Information
P-Value
0.001
Statistical Significance
p=0.001
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