KH902 Reduces Eye Damage in Monkeys
Author Information
Author(s): Zhang Ming, Zhang Junjun, Yan Mi, Li Hong, Yang Chun, Yu Dechao
Primary Institution: West China Hospital, Sichuan University, China
Hypothesis
KH902 can effectively inhibit choroidal neovascularization in a monkey model.
Conclusion
A single injection of KH902 significantly reduced leakage and growth of choroidal neovascularization in rhesus monkeys without causing toxicity.
Supporting Evidence
- KH902 binds VEGF with a mean IC50 of 10 pM.
- A single injection of 300 μg or 500 μg KH902 effectively inhibited leakage and growth of CNV.
- No toxicity was observed in the treated monkeys.
Takeaway
KH902 is a special medicine that helps stop eye problems in monkeys by blocking bad growth in their eyes.
Methodology
The study involved intravitreal injections of KH902 in rhesus monkeys with induced choroidal neovascularization, followed by various assessments including angiography and electroretinograms.
Limitations
The study was conducted on a small number of monkeys and may not fully represent human responses.
Participant Demographics
Rhesus monkeys aged 3 to 6 years, weighing between 2 and 5 kg.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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