Adherence and Blocking of Candida Albicans to Cultured Vaginal Epithelial Cells: Treatments to Decrease Adherence
2006
Reducing Candida Adherence to Vaginal Cells
publication
Evidence: moderate
Author Information
Author(s): Cara Hollmer, Michael Ault, Kevin Larsen, Bryan Larsen
Primary Institution: Des Moines University
Hypothesis
Can commercially available products reduce the adherence of Candida albicans to vaginal epithelial cells?
Conclusion
The study found that certain products can significantly reduce the binding of Candida to vaginal epithelial cells.
Supporting Evidence
- Fluorescein-labeled Candida cells effectively bound to cultured vaginal epithelial cells.
- Commercially available products reduced Candida binding by 25% to 50%.
- Vaginal epithelial cells showed increased binding when overgrown.
Takeaway
This study looked at how well yeast sticks to vaginal cells and found that some products can help stop that from happening.
Methodology
Vaginal epithelial cells were cultured and exposed to fluorescein-labeled Candida to evaluate adherence using flow cytometry.
Limitations
The study used cultured cells that may not fully represent the in vivo conditions of vaginal epithelial cells.
Digital Object Identifier (DOI)
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