MDM2 SNP309 and Breast Cancer
Author Information
Author(s): Paulin Fiona EM, O'Neill Mary, McGregor Gillian, Cassidy Andrew, Ashfield Alison, Ali Clinton W, Munro Alastair J, Baker Lee, Purdie Colin A, Lane David P, Thompson Alastair M
Primary Institution: University of Dundee
Hypothesis
Is MDM2 SNP309 associated with breast cancer characteristics in a Scottish population?
Conclusion
SNP309G/G is associated with poor prognostic breast cancer features in the Scottish population.
Supporting Evidence
- SNP309G/G genotype was associated with high grade tumours.
- The 309G/G genotype was linked to greater nodal involvement.
- No association was found between SNP309 and earlier age of cancer diagnosis.
Takeaway
This study looked at a gene variant in breast cancer patients and found that one specific version of the gene is linked to more serious cancer cases.
Methodology
The study sequenced MDM2 intron 1 from 299 breast cancer patients and 275 cancer-free controls and compared the results with clinical parameters.
Potential Biases
Potential selection bias due to the specific population studied.
Limitations
The study's sample size may not be large enough to draw definitive conclusions about the associations observed.
Participant Demographics
Scottish Caucasian population, including 299 breast cancer patients and 275 cancer-free controls.
Statistical Information
P-Value
0.025
Confidence Interval
1.06–2.53
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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