Securin (hPTTG1) expression is regulated by β-catenin/TCF in human colorectal carcinoma
2006
Securin Expression in Colorectal Cancer
Sample size: 30
publication
Evidence: high
Author Information
Author(s): Hlubek F, Pfeiffer S, Budczies J, Spaderna S, Jung A, Kirchner T, Brabletz T
Primary Institution: Ludwig-Maximilians University of Munich
Hypothesis
Is securin a target gene of β-catenin/TCF signaling in colorectal cancer?
Conclusion
Securin is overexpressed in colorectal cancer due to β-catenin activation, which may contribute to tumor progression.
Supporting Evidence
- Securin is significantly overexpressed in colorectal cancer compared to normal mucosa.
- High expression of securin correlates with nuclear β-catenin and Ki-67 expression in colorectal adenoma and carcinoma.
- β-Catenin activates the securin promoter in colorectal cancer cell lines.
Takeaway
This study found that a protein called securin is made in large amounts in colon cancer, and this is controlled by another protein called β-catenin.
Methodology
The study used tissue specimens from colorectal adenocarcinomas and performed immunohistochemistry and DNA microarray analysis.
Participant Demographics
Patients who underwent surgery for colorectal adenocarcinomas.
Statistical Information
P-Value
<0.00001
Statistical Significance
p<0.00001
Digital Object Identifier (DOI)
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