Genetic Effects on Obesity in American Indians with Diabetes
Author Information
Author(s): Franceschini Nora, Almasy Laura, MacCluer Jean W, Göring Harald HH, Cole Shelley A, Diego Vincent P, Laston Sandra, Howard Barbara V, Lee Elisa T, Best Lyle G, Fabsitz Richard R, North Kari E
Primary Institution: University of North Carolina, Chapel Hill, NC, USA
Hypothesis
The study aims to localize genetic effects on obesity traits in American Indians while accounting for diabetes status.
Conclusion
Distinct genetic effects on body mass were found in individuals with diabetes compared to those without, particularly linked to a gene on chromosome 1.
Supporting Evidence
- 57% of participants were obese (BMI > 30 kg/m2).
- 26% of participants had diabetes.
- Diabetic individuals had higher mean weight, BMI, WHR, and percentage of body fat than non-diabetic individuals.
- A QTL for weight was identified on chromosome 1 at 242 cM.
- The adiponectin receptor 1 gene is located in the identified QTL region.
Takeaway
This study found that some genes affecting weight are different for people with diabetes compared to those without it, especially in American Indians.
Methodology
The study used genome-wide linkage scans and variance component linkage analysis to identify genetic influences on obesity traits.
Limitations
The findings are limited to American Indian populations and may not be generalizable to other ethnic groups.
Participant Demographics
Participants were American Indians from Arizona, North and South Dakota, and Oklahoma, with a mean age of 42 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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