Oestrogen Receptors in Cervical Adenocarcinoma
Author Information
Author(s): S.M. Ismail, G.A. Thomas, F.A. Ghandour, H.G. Davies, R. Attanoos, E.D. Williams
Primary Institution: University of Wales College of Medicine
Hypothesis
Do oestrogens play a role in the pathogenesis of cervical adenocarcinoma?
Conclusion
Cervical adenocarcinomas contain oestrogen receptors, and their presence is associated with a better prognosis.
Supporting Evidence
- Six of 20 cervical adenocarcinomas were ER positive on immunocytochemistry.
- All cervical adenocarcinomas were positive for ER mRNA.
- Patients with ER positive tumours had a mean disease-free survival of 43.5 months.
Takeaway
This study looked at 20 cervical cancer samples to see if they had oestrogen receptors. They found that some did, and those patients did better.
Methodology
Immunocytochemistry and in situ hybridization were used to assess ER protein and mRNA in cervical adenocarcinomas.
Limitations
The study is preliminary and based on a small sample size.
Participant Demographics
Patients with cervical adenocarcinomas, mean age 50.7 years.
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