SHIV-1157i Causes AIDS in Rhesus Monkeys
Author Information
Author(s): Humbert Michael, Rasmussen Robert A, Song Ruijiang, Ong Helena, Sharma Prachi, Chenine Agnès L, Kramer Victor G, Siddappa Nagadenahalli B, Xu Weidong, Else James G, Novembre Francis J, Strobert Elizabeth, O'Neil Shawn P, Ruprecht Ruth M
Primary Institution: Dana-Farber Cancer Institute
Hypothesis
Can SHIV-1157i and its progeny viruses cause AIDS in rhesus monkeys?
Conclusion
The study shows that SHIV-1157i and its variants can induce AIDS in rhesus monkeys, mimicking the disease progression seen in humans.
Supporting Evidence
- Two monkeys remained healthy while four developed AIDS over time.
- Opportunistic infections were observed in progressor monkeys.
- SHIV-1157i was shown to be mucosally transmissible.
Takeaway
Researchers used monkeys to see if a virus similar to HIV could make them sick, and it did, just like in humans.
Methodology
The study involved infecting six rhesus monkeys with SHIV-1157i and monitoring their health over time.
Limitations
The study is limited by the small sample size and the specific animal model used.
Participant Demographics
All participants were rhesus monkeys (Macaca mulatta) of Indian origin.
Digital Object Identifier (DOI)
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