Whole grain, bran, and germ intake and risk of type 2 diabetes: A prospective cohort study and systematic review
2007

Whole Grain Intake and Type 2 Diabetes Risk

Sample size: 161737 publication 10 minutes Evidence: high

Author Information

Author(s): Jeroen S. L. de Munter, Frank B. Hu, Donna Spiegelman, Mary Franz, Rob M. van Dam

Primary Institution: Harvard School of Public Health

Hypothesis

Does higher intake of whole grains reduce the risk of developing type 2 diabetes?

Conclusion

Higher whole grain intake is linked to a lower risk of type 2 diabetes, especially for bran compared to germ.

Supporting Evidence

  • The study documented 6,486 cases of type 2 diabetes during follow-up.
  • A two-serving-per-day increase in whole grain intake was associated with a 21% decrease in diabetes risk.
  • The relative risk for the highest versus lowest quintile of whole grain intake was 0.63.

Takeaway

Eating more whole grains, like whole wheat and oats, can help keep you from getting type 2 diabetes.

Methodology

The study followed 161,737 women from the Nurses' Health Studies over 12-18 years, assessing their dietary intake and diabetes incidence.

Potential Biases

Higher whole grain intake may be associated with a generally healthier lifestyle, which could bias results.

Limitations

Potential residual confounding and measurement error in dietary intake assessment.

Participant Demographics

US women aged 26-65, primarily white.

Statistical Information

P-Value

<0.001

Confidence Interval

95% CI 0.57–0.69

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1371/journal.pmed.0040261

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