Deptor's Role in Heart Injury from Ischemia-Reperfusion
Author Information
Author(s): Duan Qunjun, Yang Weijun, Zhu Xian, Feng Zhanzeng, Song Jiangwei, Xu Xiaobin, Kong Minjian, Mao Jiayan, Shen Jian, Deng Yuqin, Tao Rujia, Xu Hongfei, Chen Wei, Li Weidong, Dong Aiqiang, Han Jie
Primary Institution: The Second Affiliated Hospital of Zhejiang University School of Medicine
Hypothesis
Deptor could inhibit mTOR pathway activation and promote autophagy.
Conclusion
Deptor protects against ischemia-reperfusion injury in the heart by regulating the mTOR pathway and enhancing autophagy.
Supporting Evidence
- Deptor knockout mice showed increased myocardial infarction size and apoptosis.
- Treatment with OSI027 reduced infarction size and apoptosis in Deptor knockout models.
- Deptor siRNA reduced cell viability and increased apoptosis in vitro.
Takeaway
Deptor is a protein that helps protect the heart from damage when blood flow is restored after being blocked. When Deptor is missing, the heart gets hurt more.
Methodology
Deptor knockout mice were used to study the effects on myocardial ischemia-reperfusion injury, with various assays to measure infarction size, apoptosis, and protein expression.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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