Effect of Matrigel on Tumor Growth in Mice
Author Information
Author(s): P. Topley, D.C. Jenkins, E.A. Jessup, J.N. Stables
Primary Institution: Wellcome Research Laboratories
Hypothesis
Does the co-injection of reconstituted basement membrane components (Matrigel) enhance the growth of human tumor cell lines in nude mice?
Conclusion
Matrigel significantly enhances the growth and tumorigenicity of certain human tumor cell lines in nude mice.
Supporting Evidence
- Matrigel improved tumor growth rates in three out of four tested cell lines.
- The growth rate of SW480 xenografts was significantly enhanced when co-injected with Matrigel.
- A549 cells showed increased tumorigenicity when co-injected with Matrigel.
Takeaway
Matrigel helps tumors grow better in mice, making it easier to study cancer.
Methodology
The study involved co-injecting human tumor cell lines with Matrigel into nude mice and measuring tumor growth and characteristics.
Limitations
The study only tested a limited number of cell lines and did not explore all potential effects of Matrigel.
Participant Demographics
Male athymic CD 1 (nu/nu) mice, aged 4 to 8 weeks.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
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